Relevance of abeta1-42 intrahippocampal injection as an animal model of inflamed Alzheimer's disease brain.

@article{McLarnon2008RelevanceOA,
  title={Relevance of abeta1-42 intrahippocampal injection as an animal model of inflamed Alzheimer's disease brain.},
  author={James G. McLarnon and Jae Kwang Ryu},
  journal={Current Alzheimer research},
  year={2008},
  volume={5 5},
  pages={475-80}
}
Injection of amyloid-beta peptide (Abeta1-42) into hippocampal and cortical regions of brain may have utility as an animal model of Alzheimer's disease (AD) emphasizing the inflammatory component of disease pathology. This review summarizes recent evidence supporting the relevance of the peptide injection model to describe inflammatory conditions in AD… CONTINUE READING