Relevance of UDP-glucuronosyltransferase polymorphisms for drug dosing: A quantitative systematic review.

Abstract

UDP-glucuronosyltransferases (UGT) catalyze the biotransformation of many endobiotics and xenobiotics, and are coded by polymorphic genes. However, knowledge about the effects of these polymorphisms is rarely used for the individualization of drug therapy. Here, we present a quantitative systematic review of clinical studies on the impact of UGT variants on… (More)
DOI: 10.1016/j.pharmthera.2013.09.002

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