Relevance of RH variants in transfusion of sickle cell patients.

  title={Relevance of RH variants in transfusion of sickle cell patients.},
  author={France Noizat-Pirenne and Christophe Tournamille},
  journal={Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine},
  volume={18 5-6},
Transfusion remains the main treatment of sickle cell disease patients. Red cell alloimmunization is frequent because of the antigen disparities between patients of African descent and donors of European ancestry. Alloimmunization is associated with severe hemolytic transfusion reaction, autoantibody formation, and difficulties in the management of… CONTINUE READING