Relevance of Helicobacter pylori vacA 3'-end Region Polymorphism to Gastric Cancer.

@article{Bakhti2016RelevanceOH,
  title={Relevance of Helicobacter pylori vacA 3'-end Region Polymorphism to Gastric Cancer.},
  author={Seyedeh Zahra Bakhti and Saeid Latifi-Navid and Shiva Mohammadi and Saber Zahri and Fatemeh Sadat Bakhti and Farideh Feizi and Abbas Yazdanbod and Farideh Siavoshi},
  journal={Helicobacter},
  year={2016},
  volume={21 4},
  pages={305-16}
}
BACKGROUND Helicobacter pylori vacA genotypes play an important role in the pathogenesis of severe gastrointestinal disease. MATERIALS AND METHODS We identified a novel polymorphic site in the 3'-end region of H. pylori vacA gene, denoted by c1/-c2 (c1: with deletion of 15 bp), and examined associations of this and the previous four sites as well as cagA status with gastroduodenal diseases, in a total of 217 Iranian H. pylori isolates. Histopathologic evaluations were performed and patients… CONTINUE READING