Relevance and Therapeutic Possibility of PTEN-Long in Renal Cell Carcinoma

@inproceedings{Wang2015RelevanceAT,
  title={Relevance and Therapeutic Possibility of PTEN-Long in Renal Cell Carcinoma},
  author={Hui Wang and Peng Zhang and Chunhua Lin and Qingxia Yu and Jitao Wu and Lin Wang and Yupeng Cui and Ke Wang and Zhenli Gao and Hong Li},
  booktitle={PloS one},
  year={2015}
}
PTEN-Long is a translational variant of PTEN (Phosphatase and Tensin Homolog). Like PTEN, PTEN-Long is able to antagonize the PI3K-Akt pathway and inhibits tumor growth. In this study, we investigated the role PTEN-Long plays in the development and progression of clear cell renal cell carcinoma (ccRCC) and explored the therapeutic possibility using proteinaceous PTEN-Long to treat ccRCC. We found that the protein levels of PTEN-Long were drastically reduced in ccRCC, which was correlated with… CONTINUE READING

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