Releasing the brake on the immune system: ipilimumab in melanoma and other tumors.

@article{Tarhini2010ReleasingTB,
  title={Releasing the brake on the immune system: ipilimumab in melanoma and other tumors.},
  author={Ahmad A Tarhini and Ernest Lo and David R. Minor},
  journal={Cancer biotherapy & radiopharmaceuticals},
  year={2010},
  volume={25 6},
  pages={601-13}
}
Advanced melanoma has proven difficult to treat for many years, and no previous agent has shown improved survival in a phase 3 trial. The deepening understanding of tumor immunobiology and the complexity of the interactions between host T cells and cancer have led to novel treatment approaches. Among these, ipilimumab is a first-in-class T-cell potentiator that works by blocking cytotoxic T-lymphocyte antigen-4, a critical negative regulator of the antitumor T-cell response. From phase 1… CONTINUE READING
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