Releasing pressure in tumors: what do we know so far and where do we go from here? A review.

@article{Ariffin2014ReleasingPI,
  title={Releasing pressure in tumors: what do we know so far and where do we go from here? A review.},
  author={A. B. Ariffin and Patrick F. Forde and Saleem Muhammad Jahangeer and D. Soden and John Hinchion},
  journal={Cancer research},
  year={2014},
  volume={74 10},
  pages={
          2655-62
        }
}
Tumor interstitial pressure is a fundamental feature of cancer biology. Elevation in tumor pressure affects the efficacy of cancer treatment. It causes heterogenous intratumoral distribution of drugs and macromolecules. It also causes the development of hypoxia within tumor bulk, leading to reduced efficacy of therapeutic drugs and radiotherapy. Tumor pressure has been associated with increased metastatic potential and poor prognosis in some tumors. The formation of increased pressure in solid… 
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