Release-regulating GABAA receptors are present on noradrenergic nerve terminals in selective areas of the rat brain.

Abstract

The effects of gamma-aminobutyric acid (GABA) on the spontaneous release of [3H]-norepinephrine ([3H]-NE) were investigated by means of superfused synaptosomes prepared from different areas of the rat brain and prelabeled with [3H]-NE. GABA increased in a concentration-dependent way (1-300 microM) the release of [3H]-NE in hippocampal synaptosomes. The… (More)

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