Release of vasoactive substances from endothelial cells by shear stress and purinergic mechanosensory transduction.

@article{Burnstock1999ReleaseOV,
  title={Release of vasoactive substances from endothelial cells by shear stress and purinergic mechanosensory transduction.},
  author={Geoffrey Burnstock},
  journal={Journal of anatomy},
  year={1999},
  volume={194 ( Pt 3)},
  pages={335-42}
}
The evidence for release of vasoactive substances from endothelial cells in response to shear stress caused by the viscous drag of passing fluids is reviewed and, in particular, its physiological significance both in short-term regulation of blood vessel tone and in long-term regulation of cell growth, differentiation, proliferation, and cell death in pathophysiological conditions is discussed. A new concept of purinergic mechanosensory transduction, particularly in relation to nociception, is… CONTINUE READING
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