Release of tissue-type plasminogen activator by activated rat eggs and its possible role in the zona reaction.

@article{Zhang1992ReleaseOT,
  title={Release of tissue-type plasminogen activator by activated rat eggs and its possible role in the zona reaction.},
  author={X Zhang and Jennifer Rutledge and Firouz Khamsi and David T Armstrong},
  journal={Molecular reproduction and development},
  year={1992},
  volume={32 1},
  pages={28-32}
}
The resumption of meiosis results in synthesis of tissue-type plasminogen activator (tPA) in the rat and mouse oocytes (Haurte et al., Cell 43:551-558, 1985). The present study demonstrates that freshly ovulated rat oocytes released their tPA into the surrounding medium upon in vitro activation by sperm penetration or treatment with a calcium ionophore. The presence of a neutralizing monoclonal anti-tPA antibody during in vitro activation by the calcium ionophore inhibited the activation… CONTINUE READING