Release of tachykinins by histamine, methacholine, PAF, LTD4, and substance P from guinea pig lungs.

@article{Martins1991ReleaseOT,
  title={Release of tachykinins by histamine, methacholine, PAF, LTD4, and substance P from guinea pig lungs.},
  author={Milton A Martins and Stephanie A. Shore and Jeffrey M Drazen},
  journal={The American journal of physiology},
  year={1991},
  volume={261 6 Pt 1},
  pages={L449-55}
}
The release of substance P- and neurokinin A-like immunoreactivities (SP-LI and NKA-LI) after tracheal infusion of histamine, methacholine, leukotriene D4, and platelet-activating factor was measured in isolated guinea pig lungs superfused through the trachea. Infusion of each of these agonists was associated with a significant (P less than 0.05) increase in the recovery of both SP-LI and NKA-LI from lung perfusates compared with preinfusion baseline recoveries of these peptides. After infusion… CONTINUE READING

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