Release of substance P from the spinal dorsal horn is enhanced in polyarthritic rats.

@article{Oku1987ReleaseOS,
  title={Release of substance P from the spinal dorsal horn is enhanced in polyarthritic rats.},
  author={Ryoya Oku and Masamichi Satoh and Hiroshi Takagi},
  journal={Neuroscience letters},
  year={1987},
  volume={74 3},
  pages={315-9}
}
Using in situ spinal dorsal horn perfusing method in decerebrated rats, we measured the release of immunoreactive substance P (iSP) in polyarthritic rats. The spontaneous release of iSP from the dorsal horn in the polyarthritic rats was significantly accelerated over that in control non-inflamed rats. Passive movements of the inflamed ankle joint evoked a significant increase in the release of iSP, while a similar movement of the non-inflamed joint led to no such increase. These results suggest… CONTINUE READING

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