Release of soluble urokinase receptor from vascular cells.

  title={Release of soluble urokinase receptor from vascular cells.},
  author={Triantafyllos Chavakis and Antje Willuweit and Florea Lupu and Klaus Theo Preissner and Sandip M Kanse},
  journal={Thrombosis and haemostasis},
  volume={86 2},
Urokinase-type plasminogen activator (uPA) and its cell surface-receptor (uPAR) regulate cellular functions linked to adhesion and migration and contribute to pericellular proteolysis in tissue remodelling processes. Soluble uPAR (suPAR) is present in the circulation, peritoneal and ascitic fluid and in the cystic fluid from ovarian cancer. We have investigated the origin and the vascular distribution of the soluble receptor, which accounts for 10-20% of the total receptor in vascular… CONTINUE READING
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