Release of soluble CD40L from platelets is regulated by glycoprotein IIb/IIIa and actin polymerization.

@article{Furman2004ReleaseOS,
  title={Release of soluble CD40L from platelets is regulated by glycoprotein IIb/IIIa and actin polymerization.},
  author={Mark I. Furman and Lori A Krueger and Matthew Dean Linden and Marc R. Barnard and Andrew L. Frelinger and Alan D Michelson},
  journal={Journal of the American College of Cardiology},
  year={2004},
  volume={43 12},
  pages={2319-25}
}
OBJECTIVES The purpose of this study was to examine the effects of glycoprotein (GP) IIb/IIIa antagonists (abciximab, eptifibatide, and tirofiban) and other inhibitors on translocation of CD40L from intraplatelet stores to the platelet surface and on the release of soluble CD40L (sCD40L) from platelets. BACKGROUND CD40L is a proinflammatory and prothrombotic ligand in the tumor necrosis factor family. METHODS Platelet surface CD40L was measured by flow cytometry, and sCD40L was measured by… CONTINUE READING