Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation

@inproceedings{Lasserre2011ReleaseOS,
  title={Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation},
  author={R{\'e}mi Lasserre and C{\'e}line Cuche and Ronnie Blecher-Gonen and Evgeny Libman and Elise Biquand and Anne Danckaert and Deborah Yablonski and Andr{\'e}s Alcover and Vincenzo Di Bartolo},
  booktitle={The Journal of cell biology},
  year={2011}
}
Antigen recognition within immunological synapses triggers and sustains T cell activation by nucleating protein microclusters that gather T cell receptors (TCRs), kinases, and adaptors. Dissipation of these microclusters results in signal termination, but how this process is regulated is unclear. In this paper, we reveal that release of the adaptors SLP76 and GADS from signaling microclusters is induced by the serine/threonine protein kinase HPK1 and that phosphorylation of GADS plays a major… CONTINUE READING

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