Release of prostaglandin E2 by microfilariae of Wuchereria bancrofti and Brugia malayi.

@article{Liu1992ReleaseOP,
  title={Release of prostaglandin E2 by microfilariae of Wuchereria bancrofti and Brugia malayi.},
  author={Luzheng Liu and Janet E. Buhlmann and Peter F. Weller},
  journal={The American journal of tropical medicine and hygiene},
  year={1992},
  volume={46 5},
  pages={520-3}
}
To elucidate the local release of immunomodulatory prostaglandins by intravascular filarial parasites, the formation of prostaglandin E2 (PGE2) was examined in individual microfilariae of Wuchereria bancrofti and Brugia malayi. Following incubation of living microfilariae immobilized in an agar matrix, prostaglandins released by the parasites were fixed by carbodiimide and localized by indirect immunofluorescence. Prostaglandin E2 was specifically detected around the entire surface of… CONTINUE READING

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