Release of potential immunomodulatory factors during platelet storage.

@article{Cognasse2006ReleaseOP,
  title={Release of potential immunomodulatory factors during platelet storage.},
  author={Fabrice Cognasse and Françoise Boussoulade and Patricia Chavarin and Sophie Acquart and Patrick Fabrigli and Bernard Lamy and Olivier Garraud},
  journal={Transfusion},
  year={2006},
  volume={46 7},
  pages={1184-9}
}
BACKGROUND Blood platelets (PLTs) link the processes of hemostasis and inflammation. Recent studies have demonstrated that PLTs promote immunity and inflammation mainly by means of the CD40/CD40L pathway. Our objective was to describe the accumulation of cytokines in PLT concentrates during storage. STUDY DESIGN AND METHODS Pools of PLT concentrates were prepared, separated from plasma, and resuspended in clinical-grade storage medium; samples were taken on Days 0, 1, 2, 3, and 5 for analysis… CONTINUE READING

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Over time , the levels of RANTES , IL-8 , and IL-6 were stable .
Over time , the levels of RANTES , IL-8 , and IL-6 were stable .
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