• Corpus ID: 29887528

Release of iron from haemoglobin--a possible source of free radicals in diabetes mellitus.

  title={Release of iron from haemoglobin--a possible source of free radicals in diabetes mellitus.},
  author={Manoj Kar and Abhay Sankar Chakraborti},
  journal={Indian journal of experimental biology},
  volume={37 2},
Increased blood glucose in diabetes mellitus stimulates nonenzymatic glycosylation of several proteins, including haemoglobin. Although iron is tightly bound to haemoglobin, it is liberated under specific circumstances yielding free reactive iron. Studies with purified haemoglobin from normal individuals and diabetic patients revealed that concentration of free iron was significantly higher in the latter cases and increased progressively with extent of the disease. In vitro glycosylation of… 

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