Release of intracellular calcium and modulation of membrane currents by caffeine in bull-frog sympathetic neurones.

@article{Marrion1992ReleaseOI,
  title={Release of intracellular calcium and modulation of membrane currents by caffeine in bull-frog sympathetic neurones.},
  author={Neil V. Marrion and Paul R. Adams},
  journal={The Journal of physiology},
  year={1992},
  volume={445},
  pages={
          515-35
        }
}
1. Calcium release and sequestration were studied in whole-cell voltage-clamped bull-frog sympathetic neurones by image analysis of Fura-2 signals. 2. Application of caffeine (10 mM) to cells voltage clamped at -38 mV caused a rapid increase in intracellular calcium concentration ([Ca2+]i) to a mean value of 352 +/- 33 nM, which activated an outward current. In the continued presence of caffeine the rise in [Ca2+]i slowly declined to a sustained plateau of 196 +/- 20 nM (112 nM above control… CONTINUE READING

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