Release of intact, monomeric cytochrome c from apoptotic and necrotic cells

Abstract

Cytochrome c (Cyt c) has been shown to translocate from mitochondria to the cytoplasm of cells early in apoptosis. In this study sandwich ELISAs for Cyt c were used to determine if Cyt c is ultimately released from apoptotic and necrotic cells. Gel-filtration and cation-exchange chromatographies, in conjunction with immunoreactivity in ELISA, and Western… (More)
DOI: 10.1038/sj.cdd.4400981

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