Release of inflammatory mediators by noxious stimuli; effect of neurotropin on the release.

@article{Ohara1988ReleaseOI,
  title={Release of inflammatory mediators by noxious stimuli; effect of neurotropin on the release.},
  author={Hirotaka Ohara and A Namimatsu and Kenichiro Fukuhara and Hisashi Yago and Reiki Yoneda and Keiko Saito and Reizo Inoki},
  journal={European journal of pharmacology},
  year={1988},
  volume={157 1},
  pages={93-9}
}
Anesthetized rats were perfused with saline in the subcutaneous space of the hind paw and the release of inflammatory mediators induced by noxious stimuli was studied. Not only immunoreactive bradykinin (BK) but also histamine, serotonin (5-HT) and immunoreactive prostaglandin E2 (PGE2) were found to be released into the perfusate when the paw was pinched. Neurotropin, used clinically as an analgesic and anti-allergic drug in Japan, inhibited the release of BK in dose-dependent manner without… CONTINUE READING