Release of histamine from rat mast cells by the complement peptides C3a and C5a.

@article{Johnson1975ReleaseOH,
  title={Release of histamine from rat mast cells by the complement peptides C3a and C5a.},
  author={A. R. Johnson and Tony E. Hugli and HANS J. MUELLER-EBERHARD},
  journal={Immunology},
  year={1975},
  volume={28 6},
  pages={1067-80}
}
Suspensions of rat mast cells were used to study the histamine-releasing actions of anaphylatoxins C3A and C5a in vitro. The peptides, derived from human or porcine complement proteins C3 and C5, were less potent than 48/80 but more potent than bradykinin in stimulating release of histamine from mast cells. The pattern of release resembled that of the anaphylactic release action, e.g. release was limited to less than 30 per cent of the cell histamine, the reaction was calcium-dependent and was… CONTINUE READING

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