Release of histamine from hamster mast cells by concanavalin A and phytohemagglutinin.

  title={Release of histamine from hamster mast cells by concanavalin A and phytohemagglutinin.},
  author={W. Alexander Van Hook and Stephen Dougherty and Joost J Oppenheim},
  journal={Infection and immunity},
  volume={9 5},
Concanavalin A (Con A) and phytohemagglutinin (PHA) released histamine from hamster mast cells incubated in a serum-free medium. Concentrations of Con A and PHA approximating those optimal for transforming lymphocytes also released maximal amounts of histamine without apparent cytotoxicity. Higher concentrations of mitogen inhibited both lymphocyte transformation and histamine release. Incubation at 37 C for 15 min released histamine, although longer times were more effective. Supernatants from… CONTINUE READING

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