Release of heat shock protein 70 and the effects of extracellular heat shock protein 70 on the production of IL-10 in fibroblast-like synoviocytes

@article{Luo2008ReleaseOH,
  title={Release of heat shock protein 70 and the effects of extracellular heat shock protein 70 on the production of IL-10 in fibroblast-like synoviocytes},
  author={Xinjing Luo and Xiaoxia Zuo and Bing Zhang and Lan Song and Xing Wei and Yaou Zhou and Xian-Zhong Xiao},
  journal={Cell Stress and Chaperones},
  year={2008},
  volume={13},
  pages={365-373}
}
It has recently been suggested that heat shock protein (Hsp) 70, an intracellular protein, can be released into the extracellular compartment and exert important immunomodulatory functions. Although elevated Hsp70 has been found in synovial fluid from patients with rheumatoid arthritis (RA), its sources and extracellular functions remain unclear. In this study, we explored whether stress response such as heat stress or exposure to tumor necrosis factor-α (TNF-α) could induce Hsp70 release from… CONTINUE READING
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