Release of gelonin from endosomes and lysosomes to cytosol by photochemical internalization.

  title={Release of gelonin from endosomes and lysosomes to cytosol by photochemical internalization.},
  author={P K Selbo and Kirsten Sandvig and Vida Kirveliene and Kristian Berg},
  journal={Biochimica et biophysica acta},
  volume={1475 3},
Gelonin, a type I ribosome-inactivating plant toxin, executes N-glycosidase activity on eukaryotic ribosomes. However, on intact cells, gelonin is relatively non-toxic, due to an incapability to penetrate cell membranes. Recently, a novel method, photochemical internalization (PCI), was invented for the translocation of membrane-impermeable molecules including gelonin to the cytosol [K. Berg et al., Cancer Res. 59 (1999) 1180-1183]. The combination of gelonin and photoactivation of endosomal… CONTINUE READING


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