Release of doxorubicin from peritoneal macrophages exposed in vivo to doxorubicin-containing liposomes.

@article{Storm1988ReleaseOD,
  title={Release of doxorubicin from peritoneal macrophages exposed in vivo to doxorubicin-containing liposomes.},
  author={G-R. Storm and Peter A. Steerenberg and F. Emmen and M van Borssum Waalkes and Daan J A Crommelin},
  journal={Biochimica et biophysica acta},
  year={1988},
  volume={965 2-3},
  pages={
          136-45
        }
}
Intracellular depot formation may be an important component of the mode of action of doxorubicin (DXR)-containing liposomes. In this paper it was investigated whether it is possible that DXR is released from macrophages which have taken up DXR-containing liposomes in vivo. Macrophages were harvested from the peritoneal cavity of LOU/M rats after i.p. administration of DXR-liposomes. Two different liposome types were used for this investigation. The amount of DXR associated with macrophages was… CONTINUE READING
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