Release of cytochrome c from mitochondria precedes Bax translocation/activation in Triton X-100-induced apoptosis.

@article{Sawai2008ReleaseOC,
  title={Release of cytochrome c from mitochondria precedes Bax translocation/activation in Triton X-100-induced apoptosis.},
  author={Hirofumi Sawai and Naochika Domae},
  journal={Leukemia research},
  year={2008},
  volume={32 3},
  pages={445-53}
}
The precise mechanisms by which sublytic concentrations of detergents induce apoptosis remain unclear. Recent studies reported the ability of nonionic detergents such as Triton X-100 to induce conformational change of Bax to the active form in vitro. Here we investigated whether activation of Bax might play a role in Triton X-100-induced apoptosis in cells. Although Bax translocation/activation was inhibited by caspase inhibitors, cytochrome c release from mitochondria was not affected in… CONTINUE READING