Release of bluetongue virus-like particles from insect cells is mediated by BTV nonstructural protein NS3/NS3A.

Recombinant baculoviruses and immunoelectron microscopy have been used to demonstrate the association of virus-like particles (VLPs) of bluetongue virus (i.e., particles composed of BTV, VP2, VP3, VP5, and VP7 proteins) and the cell cytoskeleton, as well as the release of such particles from infected cells in the presence of BTV NS3/NS3A, but not when BTV… CONTINUE READING