Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices.

Abstract

Proteolytic processing of the beta-amyloid protein precursor (APP) is regulated by cell-surface receptors. To determine whether neurotransmitter release in response to neuronal activation regulates APP processing in brain, we electrically depolarized superfused rat hippocampal slices and measured soluble APP derivatives released into the superfusate… (More)

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