Release of VIP- but not CGRP-like immunoreactivity by capsaicin from the human isolated small intestine.

Abstract

Exposure to capsaicin (1 microM) produced a prompt and sustained release of vasoactive intestinal polypeptide-like immunoreactivity (VIP-LI) from mucosa-free strips of human small intestine (jejunum and ileum). A second application of capsaicin, 60 min later, had no effect indicating complete desensitization, a specific feature of the action of capsaicin on sensory nerves. By contrast no release of calcitonin gene-related peptide (CGRP)-LI was produced upon the first or second application of capsaicin.

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@article{Maggi1989ReleaseOV, title={Release of VIP- but not CGRP-like immunoreactivity by capsaicin from the human isolated small intestine.}, author={Carlo A. Maggi and Paolo Santicioli and Elena del Bianco and Pierangelo Geppetti and G Barbanti and Damiano Turini and Alberto Meli}, journal={Neuroscience letters}, year={1989}, volume={98 3}, pages={317-20} }