Release of TGFβig-h3 by gastric myofibroblasts slows tumor growth and is decreased with cancer progression.

  title={Release of TGFβig-h3 by gastric myofibroblasts slows tumor growth and is decreased with cancer progression.},
  author={Chris Holmberg and Michael Quante and Islay A Steele and Jothi Dinesh Kumar and Silviya Balabanova and C{\'e}dric Duval and M{\'a}ty{\'a}s Czep{\'a}n and Zolt{\'a}n Rakonczay and Laszlo Tiszlavicz and Istvan Bodi Ilona Nemeth and Gyorgy Lazar and Zsolt Simonka and Rosalind Jenkins and P{\'e}ter Hegyi and Timothy C Wang and Graham J. Dockray and Andrea Varr{\'o}},
  volume={33 8},
Tumor progression has been linked to changes in the stromal environment. Myofibroblasts are stromal cells that are often increased in tumors but their contribution to cancer progression is not well understood. Here, we show that the secretomes of myofibroblasts derived from gastric cancers [cancer-associated myofibroblasts (CAMs)] differ in a functionally significant manner from those derived from adjacent tissue [adjacent tissue myofibroblasts (ATMs)]. CAMs showed increased rates of migration… CONTINUE READING
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