Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation

  title={Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation},
  author={Daiju Kitagawa and H. Kajiho and T. Negishi and S. Ura and T. Watanabe and T. Wada and H. Ichijo and T. Katada and H. Nishina},
  journal={The EMBO Journal},
  • Daiju Kitagawa, H. Kajiho, +6 authors H. Nishina
  • Published 2006
  • Medicine, Biology
  • The EMBO Journal
  • Stress‐activated protein kinase/c‐Jun N‐terminal kinase (SAPK/JNK) responds to a variety of stress stimuli and controls cell fates such as cell cycle entrance, apoptosis and senescence. Stimuli such as ultraviolet irradiation and chemical reagents that damage genomic DNA induce the activation of the SAPK/JNK signaling pathway. However, it is unclear how the signal arising in the nucleus owing to DNA damage is transmitted to SAPK/JNK in the cytoplasm. Here, we report that the nuclear components… CONTINUE READING
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