Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation.

@article{Kitagawa2006ReleaseOR,
  title={Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation.},
  author={Daiju Kitagawa and Hiroaki Kajiho and T. Negishi and Seiji Ura and Tomomi Watanabe and Teiji Wada and Hidenori Ichijo and Toshiaki Katada and Hiroshi Nishina},
  journal={The EMBO journal},
  year={2006},
  volume={25 14},
  pages={3286-97}
}
Stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) responds to a variety of stress stimuli and controls cell fates such as cell cycle entrance, apoptosis and senescence. Stimuli such as ultraviolet irradiation and chemical reagents that damage genomic DNA induce the activation of the SAPK/JNK signaling pathway. However, it is unclear how the signal arising in the nucleus owing to DNA damage is transmitted to SAPK/JNK in the cytoplasm. Here, we report that the nuclear components… CONTINUE READING
28 Citations
46 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 46 references

Similar Papers

Loading similar papers…