Release of Fatty Acids by Perfused Vascular Tissue in Normotensive and Hypertensive Rats

  title={Release of Fatty Acids by Perfused Vascular Tissue in Normotensive and Hypertensive Rats},
  author={Jacob Mtabaji and Mehar S. Manku and David F. Horrobin},
The release of fatty acids from perfused mesenteries of spontaneously hypertensive rats (SHR) and control Wistar-Kyoto rats (WKY) was studied. The release of the prostaglandin precursors dihomogammalinolenic acid, arachidonte acid, and ekosapentaenoic acid was reduced in SHR when compared with age-matched WKY. The release of all other fatty acids detected in the effluent was also reduced. The differences in fatty add release were evident even when tissue levels of the fatty acids were similar… 

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