Release of DNA from dead and dying lymphocyte and monocyte cell lines in vitro.

@article{Choi2004ReleaseOD,
  title={Release of DNA from dead and dying lymphocyte and monocyte cell lines in vitro.},
  author={J Choi and Charles F. Reich and David S. Pisetsky},
  journal={Scandinavian journal of immunology},
  year={2004},
  volume={60 1-2},
  pages={159-66}
}
DNA is a nuclear macromolecule that circulates in the blood where its levels can reflect the activity of inflammatory and malignant diseases. While dead and dying cells have usually been considered the source of blood DNA, the mechanisms for its release during apoptosis and necrosis are not well defined. To elucidate DNA release, an in vitro model system was used, assessing DNA in the media of living, apoptotic or necrotic Jurkat and U937 cells. Apoptosis was induced by etoposide, camptothecin… CONTINUE READING

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