• DOI:10.1038/306067A0
Corpus ID: 4359904

Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate

@article{Streb1983ReleaseOC,
  title={Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate},
  author={Holger Streb and Robin F. Irvine and Michael John Berridge and Irene Schulz},
  journal={Nature},
  year={1983},
  volume={306},
  pages={67-69}
}

• H. Streb, R. Irvine, +1 author I. Schulz
• Published 1983
• Biology, Medicine
• Nature

Activation of receptors for a wide variety of hormones and neurotransmitters leads to an increase in the intracellular level of calcium. Much of this calcium is released from intracellular stores but the link between surface receptors and this internal calcium reservoir is unknown. Hydrolysis of the phosphoinositides, which is another characteristic feature of these receptors1–3, has been implicated in calcium mobilization1. The primary lipid substrates for the receptor mechanism seem to be two… Expand