Release of C-type natriuretic peptide accounts for the biological activity of endothelium-derived hyperpolarizing factor.

@article{Chauhan2003ReleaseOC,
  title={Release of C-type natriuretic peptide accounts for the biological activity of endothelium-derived hyperpolarizing factor.},
  author={Sharmila D Chauhan and Holger Nilsson and Amrita Ahluwalia and Adrian J Hobbs},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 3},
  pages={1426-31}
}
Endothelial cells in most vascular beds release a factor that hyperpolarizes the underlying smooth muscle, produces vasodilatation, and plays a fundamental role in the regulation of local blood flow and systemic blood pressure. The identity of this endothelium-derived hyperpolarizing factor (EDHF), which is neither NO nor prostacyclin, remains obscure. Herein, we demonstrate that in mesenteric resistance arteries, release of C-type natriuretic peptide (CNP) accounts for the biological activity… CONTINUE READING
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