Release of ATP by a human retinal pigment epithelial cell line: potential for autocrine stimulation through subretinal space.

@article{Mitchell2001ReleaseOA,
  title={Release of ATP by a human retinal pigment epithelial cell line: potential for autocrine stimulation through subretinal space.},
  author={Christine Mitchell},
  journal={The Journal of physiology},
  year={2001},
  volume={534 Pt 1},
  pages={193-202}
}
1. Stimulation of purinergic receptors on retinal pigment epithelial (RPE) cells can increase the rate of fluid transport or decrease phagocytosis. This study aims to: determine whether the purine ATP can be released from RPE cells, begin probing the mechanism of any release and test whether cells degrade ATP extracellularly. 2. ATP release was monitored from cultured human ARPE-19 cells with the luciferin-luciferase assay. Biphasic release of ATP was triggered by basic fibroblast growth factor… CONTINUE READING

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