Release of [3H]GABA from in vitro preparations: comparison of the effect of DABA and beta-alanine on the K+ and protoveratrine stimulated release of [3H]GABA from brain slices and synaptosomes.

@article{Hammerstad1979ReleaseO,
  title={Release of [3H]GABA from in vitro preparations: comparison of the effect of DABA and beta-alanine on the K+ and protoveratrine stimulated release of [3H]GABA from brain slices and synaptosomes.},
  author={John P. Hammerstad and M. Lawrence Cawthon and C R Lytle},
  journal={Journal of neurochemistry},
  year={1979},
  volume={32 1},
  pages={
          195-202
        }
}
It has been proposed that the major portion of [3H]GABA released from rat cortical slices upon exposure to high K+ comes from a neuronal pool. Using carrier mediated exchange diffusion of DABA or β-alanine in the superfusion medium for GABA in the slice as a technique for manipulating neuronal and glial pools of GABA, it was found that DABA but not β-alanine substantially reduced the K+ stimulated release of [3H]GABA. The present study using synaptosomes as an in vitro model of the nerve ending… CONTINUE READING
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