Release mechanism of endothelin-1 and big endothelin-1 after stimulation with thrombin in cultured porcine endothelial cells.

@article{Kohno1992ReleaseMO,
  title={Release mechanism of endothelin-1 and big endothelin-1 after stimulation with thrombin in cultured porcine endothelial cells.},
  author={Masashi Kohno and Koji Yokokawa and Takeshi Horio and Kenichi Yasunari and Kazushige Murakawa and Masao Ikeda and Tadanao Takeda},
  journal={Journal of vascular research},
  year={1992},
  volume={29 2},
  pages={56-63}
}
Cultured porcine endothelial cells (EC) released immunoreactive endothelin-1 (ir-endothelin-1) and big endothelin-1 (ir-big endothelin-1) into the medium in a time-dependent way. Reverse-phase high-pressure liquid chromatography coupled with radioimmunoassay showed that the major component of ir-endothelin-1 corresponded to standard endothelin-1 (1-21) and that the major component of ir-big endothelin-1 corresponded to standard big endothelin-1 (porcine 1-39). This release was strongly… CONTINUE READING
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