Release-independent short-term synaptic depression in cultured hippocampal neurons.

  title={Release-independent short-term synaptic depression in cultured hippocampal neurons.},
  author={David L. Brody and David T. Yue},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={20 7},
Short-term synaptic plasticity may dramatically influence neuronal information transfer, yet the underlying mechanisms remain incompletely understood. In autapses (self-synapses) formed by cultured hippocampal neurons, short-term synaptic depression (STD) had several unusual features. (1) Reduction of neurotransmitter release probability with Cd(2+), a blocker of voltage-gated calcium channels, did not change depression. (2) Lowering [Ca(2+)](o) and/or raising [Mg(2+)](o) had little effect on… CONTINUE READING