Release from myosin V via regulated recruitment of an E3 ubiquitin ligase controls organelle localization.

@article{Yau2014ReleaseFM,
  title={Release from myosin V via regulated recruitment of an E3 ubiquitin ligase controls organelle localization.},
  author={Richard G Yau and Yutian Peng and Rajeshwari R. Valiathan and Shanda R. Birkeland and Thomas E Wilson and Lois S Weisman},
  journal={Developmental cell},
  year={2014},
  volume={28 5},
  pages={
          520-33
        }
}
Molecular motors transport organelles to specific subcellular locations. Upon arrival at their correct locations, motors release organelles via unknown mechanisms. The yeast myosin V, Myo2, binds the vacuole-specific adaptor Vac17 to transport the vacuole from the mother cell to the bud. Here, we show that vacuole detachment from Myo2 occurs in multiple regulated steps along the entire pathway of vacuole transport. Detachment initiates in the mother cell with the phosphorylation of Vac17 that… CONTINUE READING

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