Release from Th1-type immune tolerance in spleen and enhanced production of IL-5 in Peyer's patch by cholera toxin B induce the glomerular deposition of IgA.

@article{Yamanaka2016ReleaseFT,
  title={Release from Th1-type immune tolerance in spleen and enhanced production of IL-5 in Peyer's patch by cholera toxin B induce the glomerular deposition of IgA.},
  author={Takahiro Yamanaka and Hidekazu Tamauchi and Yusuke Suzuki and Hitoshi Suzuki and Satoshi Horikoshi and Masazumi Terashima and Kazuya Iwabuchi and Sonoko Habu and Ko Okumura and Yasuhiko Tomino},
  journal={Immunobiology},
  year={2016},
  volume={221 4},
  pages={577-85}
}
We examined the pathogenesis of glomerular damage in Th2 type-dependent GATA-3 transgenic (GATA-3 Tg) mice with IgA nephropathy (IgAN). GATA-3 Tg mice were immunized orally using OVA plus cholera toxin B (CTB), and measurement of the serum IgA antibody level and histopathological examination were performed. Marked increases in the serum levels of OVA… CONTINUE READING