Release and actions of adenosine in the central nervous system

  title={Release and actions of adenosine in the central nervous system},
  author={Michael J Higgins and H. Hosseinzadeh and D G Macgregor and Hamish Ogilvy and Trevor W Stone},
  journal={Pharmacy World and Science},
Adenosine is released from active neurons into the extracellular fluid at a concentration of about 1μmol/l. Neither the precise cellular origin nor the biochemical form of release has been firmly established, though the nucleotide is probably released partly directly, as a result of raised intracellular levels, and partly as nucleotides, which are subsequently hydrolysed. Once in the extracellular medium, adenosine markedly inhibits the release of excitatory neurotransmitters and modulatory… CONTINUE READING

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