Relaxing the rule of ten events per variable in logistic and Cox regression.

@article{Vittinghoff2007RelaxingTR,
  title={Relaxing the rule of ten events per variable in logistic and Cox regression.},
  author={Eric Vittinghoff and Charles E Mcculloch},
  journal={American journal of epidemiology},
  year={2007},
  volume={165 6},
  pages={710-8}
}
The rule of thumb that logistic and Cox models should be used with a minimum of 10 outcome events per predictor variable (EPV), based on two simulation studies, may be too conservative. The authors conducted a large simulation study of other influences on confidence interval coverage, type I error, relative bias, and other model performance measures. They found a range of circumstances in which coverage and bias were within acceptable levels despite less than 10 EPV, as well as other factors… CONTINUE READING
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