Relaxing activity of two linear diterpenes from Cystoseira brachycarpa var. balearica on the contractions of intestinal preparations.

@article{Piet1995RelaxingAO,
  title={Relaxing activity of two linear diterpenes from Cystoseira brachycarpa var. balearica on the contractions of intestinal preparations.},
  author={F D Piet{\`a} and Maria Cristina Breschi and R. Scatizzi and Francesco Cinelli},
  journal={Planta medica},
  year={1995},
  volume={61 6},
  pages={493-6}
}
Eleganolone (1) and elegandiol (2), two linear diterpenes isolated from Cystoseira brachycarpa var. balearica, were tested on guinea-pig intestinal preparations. Both these compounds inhibited the contractile activities of acetylcholine (Ach) and histamine (Hist) on ileum musculature; the relative pIC50 values of eleganolone were found to be 4.60 +/- 0.03 and 4.84 +/- 0.20, respectively, while those of elegandiol were 4.71 +/- 0.18 and 5.18 +/- 0.01, respectively. Furthermore, 1 and 2 dose… CONTINUE READING