Relaxin stimulates MMP-2 and alpha-smooth muscle actin expression by human periodontal ligament cells.

@article{Henneman2008RelaxinSM,
  title={Relaxin stimulates MMP-2 and alpha-smooth muscle actin expression by human periodontal ligament cells.},
  author={Seppi Henneman and Miriam M Bildt and Jeroen Degroot and Anne Marie Kuijpers-Jagtman and Johannes W. Von den Hoff},
  journal={Archives of oral biology},
  year={2008},
  volume={53 2},
  pages={161-7}
}
The main cells in the periodontal ligament (PDL) are the fibroblasts, which play an important role in periodontal remodelling. Matrix metalloproteinases (MMPs) are largely responsible for the degradation of extracellular matrix proteins in the PDL. Previous studies have indicated that MMP production can be stimulated by the hormone relaxin. This hormone facilitates delivery by softening the connective tissues of the reproductive tract, and it prepares the mammary gland for lactation… CONTINUE READING
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