Relaxin signalling in primary cultures of human myometrial cells.

@article{Heng2008RelaxinSI,
  title={Relaxin signalling in primary cultures of human myometrial cells.},
  author={Kee Heng and Richard Ivell and Prabhath T Wagaarachchi and Ravinder J K Anand-Ivell},
  journal={Molecular human reproduction},
  year={2008},
  volume={14 10},
  pages={603-11}
}
In myometrium of pigs and rats, though not humans, relaxin appears to mediate an inhibition of spontaneous and oxytocin-induced contractility, presumably acting through a G-protein coupled receptor (RXFP1) to generate cAMP. In humans, circulating relaxin is highest in the first trimester, including the time of implantation, when transitory uterine quiescence could help a blastocyst to implant. We investigated whether relaxin can activate adenylate cyclase in primary human myometrial cells from… CONTINUE READING

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