Relaxin peptide hormones are protective during the early stages of ischemic stroke in male rats.

@article{Bergeron2015RelaxinPH,
  title={Relaxin peptide hormones are protective during the early stages of ischemic stroke in male rats.},
  author={Lindsay H Bergeron and Jordan M. Willcox and Faisal J Alibhai and Barry J. Connell and Tarek M Saleh and Brian C. Wilson and Alastair J. S. Summerlee},
  journal={Endocrinology},
  year={2015},
  volume={156 2},
  pages={638-46}
}
The pregnancy hormone relaxin protects tissue from ischemic damage. The ability of relaxin-3, a relaxin paralog, to do so has not been explored. The cerebral expression levels of these peptides and their receptors make them logical targets for study in the ischemic brain. We assessed relaxin peptide-mediated protection, relative relaxin family peptide receptor (RXFP) involvement, and protective mechanisms. Sprague-Dawley rats receiving permanent (pMCAO) or transient middle cerebral artery… CONTINUE READING