Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts.

@article{Unemori1990RelaxinMS,
  title={Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts.},
  author={Elaine N Unemori and Edward P. Amento},
  journal={The Journal of biological chemistry},
  year={1990},
  volume={265 18},
  pages={10681-5}
}
Relaxin is believed to play a role in connective tissue remodeling during pregnancy (Bell, R.J., Eddie, L. W., Lester, A. R., Wood, E. C., Johnston, P.D., and Niall, H. D. (1987) Obstet. Gynecol. 69, 585-589; MacLennan, A. H. (1983) Clin. Reprod. Fertil. 2, 77-95). In the present study, normal human fibroblasts exposed to concentrations of a synthetic bioactive relaxin peptide from 0.1 to 10 ng/ml synthesized and secreted the metalloproteinase procollagenase, which was immunoprecipitable as a… CONTINUE READING

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