Relaxin is essential for systemic vasodilation and increased global arterial compliance during early pregnancy in conscious rats.

@article{Debrah2006RelaxinIE,
  title={Relaxin is essential for systemic vasodilation and increased global arterial compliance during early pregnancy in conscious rats.},
  author={Dan O Debrah and Jackie Novak and Julianna E Matthews and Rolando J J Ramirez and Sanjeev G. Shroff and Kirk P. Conrad},
  journal={Endocrinology},
  year={2006},
  volume={147 11},
  pages={5126-31}
}
During early pregnancy, there are marked increases in cardiac output (CO) and global arterial compliance (AC), as well as decreases in systemic vascular resistance (SVR). We recently reported that administration of recombinant human relaxin to nonpregnant female rats elicits changes in systemic hemodynamics and arterial mechanical properties similar to those observed during normal pregnancy. In the present study, we directly tested whether endogenous relaxin mediates the cardiovascular… CONTINUE READING